Transcriptional Regulation of Skeletal Muscle Differentiation
The aim of this research program is to characterize at the biochemical and molecular level, transcription factors and chromatin remodeling proteins regulating skeletal muscle specification and development. Thus, the interplay between non-coding RNAs such as miRNAs, enhancers-RNAs and lncRNAs with chromatin organization and genome topology in myogenesis, is of our utmost interest.
Molecular Mechanisms Mediating Muscle Fiber Type Identity
Skeletal muscles constitute about 40% of its total body mass. Most skeletal muscles are composed of a mixture of myofibers with distinct contractile, metabolic, resistance to fatigue properties, as well as differential vulnerability in pathophysiological conditions. Oxidative myofibers are more fatigue resistant and have higher mitochondrial content, to facilitate β-oxidation. Fast glycolytic myofibers fatigue more easily and rely on glycolysis for energy production.
By understanding the molecular, cellular and epigenetic mechanisms mediating fiber type identity, our aim is to identify molecular targets to therapeutically induce specific muscle fibers to ameliorate diseases affecting muscle function.
Identification of Molecules to Enhance Skeletal Muscle Regeneration
This research program includes the identification of new drugs targeting key molecular regulators with the potential to promote muscle differentiation and regeneration. Through molecular docking and molecular dynamics, our aim is to establish a solid pipeline to discover and characterize novel therapeutic drugs for tissue regeneration.